ISSN 2149-5807 | E-ISSN 2149-6048
Original Article
The Comparison of the Effects of “Trometamol; Tris-Hydroxymethylaminomethane” and “Sodium Bicarbonate” Treatments on Mortality and Survival Time in Experimental Metabolic Acidosis Induced by Methanol Intoxication
1 Department of Emergency Medicine, Dokuz Eylul University School of Medicine, Izmir, Turkey  
2 Department of Laboratory Animal Science, Dokuz Eylul University, Institute of Health Sciences, Izmir, Turkey  
3 Department of Emergency Medicine, Merkezefendi State Hospital, Manisa, Turkey  
4 Department of Emergency Medicine, Gaziemir State Hospital, Izmir, Turkey  
5 Department of Anesthesia and Reanimation, Dokuz Eylul University, Institute of Health Sciences, Izmir, Turkey  
Eurasian J Emerg Med 2018; 17: 22-27
DOI: 10.5152/eajem.2018.69772
Key Words: Metabolic acidosis, methanol, Tris-hydroxymethylaminomethane, sodium bicarbonate, rat
Abstract

 

Aim: Metabolic acidosis is the most serious complication of methanol intoxication, which needs urgent treatment. The aim of this study was to investigate effects of “Trometamol; Tris-hydroxymethylaminomethane” (THAM) and “Sodium Bicarbonate” (NaHCO3) treatments on mortality and survival time in rats with metabolic acidosis induced by intragastric-administered methanol.

 

Materials and Methods: In 21 rats, a cannula was inserted in the right common carotid artery; the esophagus of each rat was penetrated with a branul. Baseline arterial blood gas samples were taken, and a 6 g/kg dose of methanol was injected into the cannula in the esophagus. The rats with confirmed acidosis were separated into three groups as “THAM,” “NaHCO3,” and “control” for the treatments. The control group received no medication, and the THAM and NaHCO3 groups were administered corresponding treatments intravenously.

 

Results: A statistically significant difference was determined between the survival times of the THAM and NaHCO3 groups (p=0.036) and the THAM and control groups (p=0.002).

 

Conclusion: The results of this study support the use of THAM, which is a biological, low-toxicity, inert amino alcohol, instead of NaHCO3 in the treatment of metabolic acidosis induced by intragastric methanol intoxication.

 

Cite this article as: Bolatkale M, Ersoy G, Yanturali S, Yilmaz O, Can Ç, Acara A, et al. The Comparison of the Effects of “Trometamol; Tris-Hydroxymethylaminomethane” and “Sodium Bicarbonate” Treatments on Mortality and Survival Time in Experimental Metabolic Acidosis Induced by Methanol Intoxication. Eurasian J Emerg Med. 2018; 17: 22-7.

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