ISSN 2149-5807 | E-ISSN 2149-6048
Original Article
Utility of Serum S100B Level, SFSR and OESIL Scores in Anticipating Short Term Adverse Events of Discharged Syncope Patients
1 Department of Emergency Medicine, Dr. Lutfi Kirdar Kartal Education and Research Hospital, İstanbul, Turkey  
2 Department of Emergency Medicine, Marmara University Pendik Education and Research Hospital, İstanbul, Turkey  
3 Department of Emergency Medicine, Dr. Lütfi Kırdar Kartal Training and Research Hospital, İstanbul, Turkey  
4 Department of Emergency Medicine, Faculty of Medicine, Atatürk University, Erzurum, Turkey  
5 Department of Emergency Medicine, Medeniyet University, Göztepe Training and Research Hospital, İstanbul, Turkey  
Eurasian J Emerg Med 2013; 12: 1-7
DOI: 10.5152/jaem.2012.029
Key Words: S100B protein, syncope, sensitivity and specificity

Objective: Our aim is to evaluate S100β in serum in addition to clinical syncope

decision rules and to determine the utility of this parameter along with

OESIL and SFSR for any short term (10 days) adverse events.


Material and Methods: This observational prospective cohort study included

all consecutive patients older than 18 years who presented to the ED of

Marmara University Hospital between June 2005 and January 2007 with the

complaint of syncope within the previous 48 hours unless they had exclusion

criteria. Two hundred and fifty-four patients were admitted, 80 were enrolled

and 62 completed the follow-up. Multivariable logistic regression analysis

was used to develop a risk score to predict the probability any adverse event

in the short term using parameters of OESIL risk score, SFSR and serum S-100β



Results: Patients with any short term adverse events had a higher pulse rate,

lower hematocrit and hemoglobin levels, and higher serum S100B levels on

admission. There were no significant differences between the accuracies of

OESIL, SFS Rule and S100B level. Absence of prodromal symptoms, abnormal

ECG and high serum S100B level were significant contributors of the model of

adverse events. OESIL and S100B level were relatively effective compared to

SFSR. The predictive value of each risk score was increased when combined

with S100B level.


Conclusion: The OESIL and SFSR were ineffective in recognizing patients with

adverse events because of relatively low sensitivity. Serum S100B level seems

to be a promising biochemical test which may increase the utility of prognostic

syncope risk scales.

Key Words
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