Original Article

The Relationship Between Inflammatory Reagents and Mortality in Patients Over the Age of 55 Hospitalised in the Internal Medicine Intensive Care Unit from the Emergency Service


  • Hasim Onur Uluöz
  • Ahmet Sebe
  • Mehmet Oğuzhan Ay
  • Yağmur Topal
  • Ayça Açıkalın
  • Müge Gülen
  • Selen Acehan

Received Date: 13.08.2012 Accepted Date: 07.09.2012 Eurasian J Emerg Med 2013;12(1):13-18


In this study, we tried to determine the relationship between inflammatory reagents, acute phase reactants, GCS, APACHE-II, SAPS-II scores and mortality of the patients over the age of 55 hospitalised inthe internal medicine intensive care unit.

Material and Methods:

This study was planned as a prospective, randomized study and the patients hospitalized in the intensive care unit from the emergency medicine department were enrolled in this study following the ethics committee approval. A standard data collection form was prpeared to collect the data in a standard way. 48 (%65.8) male, 25 (%34.2) women and a total of 73 patients were included in our study. Blood samples were taken from each patient and white blood cell (WBC), hemoglobin, c-reactive protein (CRP), interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor-alpha (TNF-alpha), prothrombin time (PTZ), activated partial thromboplastin time (aPTT), albumin and ferritin levels were studied in our laboratory. Glasgow Coma Scale, SAPS-II and APACHE-II scores were calculated for each patient. “SPSS for Windows version 18” package program was used for statistical analysis of the data. Chi square test was used to compare categorical measures between the groups. Mann-Whitney U test and T-test were used to compare quantitative measurements between the groups.


There was no statistically significant difference in mean age among patients who died and survived . Mean duration of hospitalization inthe patient group who died was less than for the survived patients group but there was no statistically significant difference between groups. A significant relationship was found between mortality and the high levels of ferritin, aPTT, SAPS-II and the low levels of albümin, GCS. No significant relationship was found between mortality and leukocyte count, haemoglobin, PTZ, CRP, TNFalpha, IL-1, IL-6, IL-10 and APACHE-II score.


SAPS-II, GCS, ferritin, albumin, aPTT measurements were determined to be used in the mortality estimation of the patients hospitalised in the intensive care unit.

Keywords: Intensive care, SAPS-II, aPTT, albumin, ferritin, mortality