Original Article

Role of Homocysteine in Ischemic Cerebrovascular Disease


  • Fevzi Yılmaz
  • Ahmet Demircan
  • Fikret Bildik

Received Date: 02.01.2010 Accepted Date: 09.02.2010 Eurasian J Emerg Med 2010;9(3):134-142


Stroke currently comes third among mortality causes, particularly in developed countries. This study has been performed to determine whether a high level of homocysteine is an independent risk factor for ischemic cerebrovascular disease.

Materials and Methods:

This study was performed in the Adult Emergency Room of Gazi University, Emergency Medicine Department. This study is a controlled prospective study. Kolmogorov-Smirnov, Shapiro-Wilk, Student’s T test, Chi-square, and Fisher’s Exact tests were used in the evaluation of the statistical data.


Eighty-three adult patients and a group of volunteers consisting of 41 individuals were included in the study. Among the risk factors of stroke, a statistically signifi cant relation between the presence of hypertension in the medical history and high blood pressure in the physical examination was found (p<0.05).


Hyperhomositeinemia is an independent risk factor in a disease like stroke with high morbidity and mortality, and we consider that detecting and treating hyperhomosisteinemia in the early period will reduce the risk of stroke.

Keywords: Ischemic cerebrovascular disease, homocysteine